During the interview, hosted by Genius, 52-year-old legend was asked if he would ever take part in a VERZUZ broadcast, a series produced by Timbaland and Swizz Beatz in which two legendary artists perform their own hits.
"No offense," he added. "Everyone is incredible, and they've accomplished what they've set out to do." "There's no way anyone could possibly follow me on that stage."
Jay fired off the major claim during a Twitter Spaces event, where users have been tweeting their questions using #VerzuzQuestions for him and Alicia Keys to answer. Other topics included his iconic music video for "I Just Wanna Love U (Give It 2 Me)" and his advice to younger artists.
"My advice is be yourself," he said when asked for some wisdom on how he would help them in their careers. "There's really no one out there that looks or thinks like you, so just cultivate your space."
Earlier this year, Swizz Beatz teased his remix project with JAY-Z, which he said came about after the iconic rapper approached him.
"JAY heard it and loved it," Swizz told HipHopDX. "He was like, 'Man! I wanna get on this!' And so we got right to work."
The legendary producer also said that the remix version of his song "On to the Next One" is something he's been working on since 2012.
"When I did 'On To The Next One' it was one of those records that had special energy," he said at the time. "I did this beat in 2012, 2013, so when I made it there was energy behind it. When Roc-A-Fella came to me to finish this album, once I gave them the idea of doing another 'On To The Next One,' they got all excited about it."The original version of "On To The Next One" appeared on Hov's 2009 album, The Blueprint 3.